preparation | in a reaction tube, add 262mg of ethyl p-iodide (MW = 262.04,1.0mmol), then add 153mg of sodium methyl sulfonate (MW = 102.09,1.2mmol, content 80%),28mgL-proline sodium salt (MW = 137.05,0.2mmol),19mgCuI(MW = 190.45,0.1mmol),2mlDMSO is used as a solvent, under the protection of nitrogen, react in an oil bath at 80 ℃ for 36 hours, cool, add 4 ml of water, extract with 10 ml of ethyl acetate each time, repeat three times, wash the extract with saturated salt water, dry with anhydrous sodium sulfate, filter, distill the filtrate under reduced pressure, and separate it through a silica gel column (eluent petroleum ether: ethyl acetate = 3: 1) to obtain 158mg of the product 4-methylsulfonyl benzoate with a yield of 77%. |